X-Ray Fluorescence Spectrometric Determination of Total Bromide in Crude Drugs.

Abstract

An analytical procedure was developed for the determination of total bromide residues in crude drugs and their preparations, using modified X-ray fluorescence spectrometry. A 0.26 g of powdered sample mixed with 2.34 g of cellulose powder as vehicles was applied to a 40 mm i.d. aluminum ring, then pressed for one minute and set in spectrometer. The limit of the determination was 1μg/g (10μg/g as the original sample). Using the described method, cellulose powder as vehicles offers an extremely good property for mixing samples and less interference of sample matrix. We were able to eliminate the previous procedure, which is necessary to prepare standards for each part of sample due to being liable to variation. The modified X-ray method is advantageous for simple and high speed measurements and could be applied for various kinds of crude drugs and their preparations.