Abstract
E-mail: psy@ssu.ac.krReceived May 8, 2012, Accepted May 31, 2012Key Words : TIR-domain containing Adaptor Protein (TIRAP), MyD88-Adaptor Like protein (MAL), Tollsignalling, Toll/Interleukin Receptor (TIR)Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs) have integral roles in host immune and inflammatoryresponse. In TLR signalling, pathogens bind to the receptor,and stimulate the cytoplasmic Toll/interleukin-1 receptor(TIR)-domain to recruit other TIR-domain containing pro-teins. Recruitment of one or more of these TIR-domainproteins, such as MyD88, TIRAP/MAL, TRIF/TICAM-1and TIRP/TRAM/TICAM-2, to the receptors ultimatelyresults in the downstream activation of transcription factors(e.g. NF-κB), which induce genes necessary for the hostdefense.
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