Abstract
Titanium is the most widely preferred metal material for bone reconstruction in orthopedics and dentistry. To improve its biological performance, various coatings can be applied. In this investigation, a biomimetic coating on a model implant surface was studied in X-ray and neutron reflectivity experiments to probe the quality of this coating, which is only few nanometers thick. Titanium was deposited on polished silicon surfaces using a magnetron sputtering technique. To improve the lipid coating's stability, a stronger van der Waals interaction was first created between the implant surface and the biomimetic coating by adding a phosphonic acid (n-octadecylphosphonic acid - OPA) monolayer onto the surfaces. Then, three monolayers of POPE (phospholipid 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-ethanolamine) were transferred using the Langmuir-Blodgett (LB) and Langmuir-Schaefer (LS) techniques. The analysis of X-ray and neutron specular reflectivity data shows that OPA molecules cover the model implant surface completely and that approximately 50% coverage of POPE can be achieved by LB and LS transfer.
Highlights
The demands on medical implants as safe and long-term solutions for problems with the musculoskeletal system are rapidly growing due to increased life expectancy, changing lifestyles and improved implant technology [1]
The analysis of X-ray and neutron specular reflectivity data shows that n-Octadecylphosphonic acid (OPA) molecules cover the model implant surface completely and that approximately 50% coverage of Phospholipid 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-ethanolamine (POPE) can be achieved by LB and LS transfer
N-octadecylphosphoric acid was chemically deposited onto titanium surfaces and probed by X-ray and neutron specular reflectivity experiments
Summary
The demands on medical implants as safe and long-term solutions for problems with the musculoskeletal system are rapidly growing due to increased life expectancy, changing lifestyles and improved implant technology [1]. The rapid increase of the number of elderly people due to longer life expectancies and different types of degenerativedystrophic changes such as osteoarthritis and rheumatoid arthritis [3] require that implants endure longer and perform even when patients have compromised health conditions [4]. Recent scientific discoveries have provided novel insights into the biological mechanisms that are responsible for bone healing [5]. These achievements currently facilitate the development of implants that
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