Abstract

The main result of this updated release is the formal proof that 2019-nCoV coronavirus is partially a SYNTHETIC genome. We proof the CONCENTRATION in a small région of wuhan New genome (300bp) of 3 different régions from HIV1 ENVELOPPE gene and 3 others from HIV2 and SIV (ENV and POL RT). All this is remarkable and bears the mark of a desire for organization of a human nature: LOGIC, SYMETRIES.
 In this article, we demonstrate also that there is a kind of global human hosts adaptation strategy of SARS viruses as well as a strategy of global evolution of the genomes of the different strains of SARS which have emerged, mainly in China, between years 2003 first SARS genomes and the last 2019 COVID-19 Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome.
 This global strategy, this temporal link, is materialized in our demonstration by highlighting stationary numerical waves controlling the entire sequence of their genomes.
 Curiously, these digital waves characterizing the 9 SARS genomes studied here are characteristic whole numbers: the "Fibonacci numbers", omnipresent in the forms of Nature, and which our research for several decades has shown strong links with the proportions of nucleotides in DNA.
 Here we demonstrate that the complexity and fractal multiplicity of these Fibonacci numerical waves increases over the years of the emergence of new SARS strains.
 We suggest that this increase in the overall organization of the SARS genomes over the years reflects a better adaptation of SARS genomes to the human host.
 The question of a link with pathogenicity remains open.
 However, we believe that this overall strategy for the evolution of the SARS genomes ensures greater unity, consistency and integrity of the genome.
 Finally, we ask ourselves the question of a possible artificial origin of this genome, in particular because of the presence of fragments of HIV1, HIV2 and SIV retroviruses.

Highlights

  • In january 2020, Wuhan China megacity was the origin of a Novel SARS disease entitled by OMS « COVID-19 » [6]

  • As show in the following figures, we analyse in this article 9 whole SARS genomes with the goal to discover a possible strategy of SARS GENOMES EVOLUTION from 2003 original viruses to the 2020 WUHAN virus

  • SARS2004b SARS Coronavirus ZS-C, Complete Genome https://www.ncbi.nlm.nih.gov/nuccore/AY395003. In this third SARS2004b genome, we find only the Fibonacci stationary wave 5bp (Figure 15)

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Summary

Introduction

Since the SARS coronavirus emergence 18 years ago, a large number of severe acute respiratory syndrome related coronaviruses (SARSr-CoV) have been discovered in their natural host, bats. Some of those bat SARSr-CoVs have the potential to infect humans. In january 2020, Wuhan China megacity was the origin of a Novel SARS disease entitled by OMS « COVID-19 » [6]. This novel coronavirus (COVID-19) caused an epidemic of respiratory syndrome in humans, in Wuhan, China in other World countries (Iran South Korea, Italia...). As show in the following figures, we analyse in this article 9 whole SARS genomes with the goal to discover a possible strategy of SARS GENOMES EVOLUTION from 2003 original viruses to the 2020 WUHAN virus

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