Abstract
In this study, we tested for the presence of WUV in children with respiratory tract infection in Fuzhou, Fujian, China. Nasopharyngeal aspirates (NPA) were collected from children with respiratory tract infection from Nov. 2007 to Oct. 2008. A total of 58 clinical respiratory tract samples were tested for WUV by using PCR method. The positive products were sequenced and compared with those in Genbank. 4 of 58 were positive (WUV was 6.9%). All of children who were positive for WUV had respiratory manifestations. WUV was tested positive in the sputum and vomited specimen, and in the fecal specimen of one outpatient child who also had acute gastroenteritis. Co-infections with other respiratory viruses were found in 3 (75.0%) of WUV positive NPA samples. Polyomavirus WUV infection may be associated with upper and lower respiratory infection. WUV might also be transmitted through the gastrointestinal tract.
Highlights
Acute respiratory infection (ARI) is responsible for significant morbidity and mortality worldwide [1]
The two known human polyomaviruses JCV and BKV are ubiquitous human viruses which are thought to be transmitted through a respiratory or oral route at an early age [7]. They establish persistent infections, which are usually asymptomatic in immunocompetent patients but may lead to severe disease in those who are immunosuppressed in various tissues, including the kidney and brain [8,9]. Of these five human polyomaviruses, only MCV has far been strongly linked to cancer, which named Merkel cell carcinoma
The sputum and vomited specimen and the fecal specimen from one outpatient child who had acute gastroenteritis were tested for the presence of WUV
Summary
Acute respiratory infection (ARI) is responsible for significant morbidity and mortality worldwide [1]. The two known human polyomaviruses JCV and BKV are ubiquitous human viruses which are thought to be transmitted through a respiratory or oral route at an early age [7] They establish persistent infections, which are usually asymptomatic in immunocompetent patients but may lead to severe disease in those who are immunosuppressed in various tissues, including the kidney and brain [8,9]. Of these five human polyomaviruses, only MCV has far been strongly linked to cancer, which named Merkel cell carcinoma.
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