WTP2.10 A retrospective study of effect of donor obesity on fibrosis and kidney outcome in live donor kidney transplantation

Abstract

Abstract Aims Donor obesity has increased over the last decade. The aim of this study was to assess the effect of donor obesity on fibrosis in pre-implantation biopsy and kidney outcomes in live kidney transplants. Methods A series of 288 live kidney donors between 1998 and 2010 were studied. The series was divided into three groups according to the donor Body Mass Index (BMI); Normal BMI 17-24.9 (n=119), overweight BMI 25–29.9 (n=118) and obese BMI ≥30 (n=51). Donor and recipient demographics were gathered and recipient post-transplant renal function up to five years was retrieved. Fibrosis level in pre-implantation biopsies was analysed and graft and recipient survival were assessed. Results Hypertension and live kidney donor profile index LKDPI were statistically significantly higher in obese donors compared with non-obese donors (p=0.004 and p<0.001 respectively). Donor creatinine levels for obese group were comparable to the other two groups over three post-operative years (p=0.933). Fibrosis analysis showed no statistically significant difference among the three BMI groups (p=0.063). Donor obese group had statistically significant higher 5 year graft and patient loss rate compared with non-obese BMI groups (p=0.018 and p=0.015 respectively). Recipient post-operative creatinine levels showed no statistically significant differences among the three BMI groups (p=0.393). Similarly, fibrosis in pre-implantation biopsies had no statistically significant impact on recipient post-operative creatinine levels (p=0.243). Conclusions Donor obesity has no significant impact on fibrosis in the pre-implantation biopsy and on recipient post-operative kidney function. However, Donor obesity results in lower five-year graft and patient survival rate.