WTP2.1 Predictors Of Non -Adherence To Immunosuppression In Transplant Patients At A University Teaching Hospital

Abstract

Abstract Introduction To assess the degree of immunosuppressive medication adherence in kidney transplant patients (KTPs) and to determine the predictors of non-adherence. Methods From a total of 106 KTPs treated at the RLBUHT (Jan 2020- June 2021), N= 20 (18%) patients were identified as being non-adherent on two or more hospital incident episodes identified by the continued care clinic, clinicians, and pharmacy. Statistical analysis was performed using the Student t-test. The predictors were data mined with Cox Regression, with the time-variable being time to graft dysfunction or Tacrolimus level abnormality > 50% variance of average trough level (6-8 ng/ml). Results Non-Adherence was observed in 20 (18.6%) patients; the estimated glomerular filtration rate was significantly lower in the no-adherence group (28.52 ± 17.62 ml/min) than in the adherence group (62.43 ± 11.72 ml/min, p < 0.05). About the Tacrolimus trough level, a significant difference was found between the adherers and the Nonadherers (5.10 ± 2.19 vs. 3.06 ± 1.04 ng/ml, p < 0.05). Non-adherers were interrogated during clinical encounters by clinicians and interpreter requirements. Polypharmacy (N=15), (Interpreter requirement) (N=11), young patients age 18-21 (N=05), and old age>70 (N=04) were the predictors of non-adherence. The patients were re-counseled and social services were involved to minimize recurrence. Conclusion The KTPs in this study demonstrated that non-adherence was associated with worse graft function and a lower Tacrolimus level. Knowledge about the degree of adherence could help identify non-adherent patients early and develop strategies to improve outcomes.