Abstract
Wüstite-type Fe0.78Mn0.22O nanocubes, with a uniform size of ∼10 nm in edge length, have been synthesized by thermal-decomposition approach. The nanocubes exhibited superparamagnetic properties at room temperature, associated with a magnetization of 12.6 emu/g. These Fe0.78Mn0.22O nanocubes present transversal (r2) and longitudinal (r1) relaxivities of 325.9 and 0.518 mM−1 s−1 at 7 T for water protons. The ratio of the r2/r1 (629.2) ranks them being the highest sensitivity (r2/r1) comparable to currently reported T2-weighted magnetic resonance imaging (MRI) agents. Meanwhile, the Fe0.78Mn0.22O nanocubes were functionalized and demonstrated to be biocompatible when attached to the surface of mesenchymal stem cells, therefore showing the promise as a new class of MRI agents in clinic applications.
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