WS6.1 A cross-sectional evaluation of factors influencing adherence in children with cystic fibrosis

Abstract

Objectives: To evaluate adherence to enzyme supplements, vitamins and chest physiotherapy in children using a multi-method approach and to examine factors influencing adherence. Methods: Adherence to therapy was measured using scores from the self-reported parent and child ( 11 years) Medication Adherence Report Scale (MARS), prescription refill history from community pharmacy and General Practitioner prescription issue history. Adherence was determined when the participant scored 80% in all applicable measurement methods. Furthermore, beliefs about medication were assessed in children 11 years and parents using a modified Beliefs about Medicine Questionnaire (BMQ), quality of life was assessed using the Cystic Fibrosis Questionnaire-Revised and parental depressive symptoms were examined using the Center for Epidemiologic Studies Depression Scale. Results: 100 children with cystic fibrosis (birth to 18 years) and their parents were recruited from the paediatric cystic fibrosis centre at the Royal Belfast Hospital for Sick Children between November 2010 and September 2011. Adherence varied between treatment and adherence measure (Table 1). Conclusion: Logistic regression analysis indicated that increased child age and low parental necessity beliefs were significant, independent drivers of non-adherence to enzyme supplements and chest physiotherapy.