WS14.05 Effect of an agro-based compound (A-bC) on remodelling and regeneration of airway epithelium in cystic fibrosis

Abstract

The CF airway epithelium (AE) exhibits large areas of remodelling such as basal or goblet cell hyperplasia, ciliated cell absence or epithelial desquamation, therefore leading to impaired mucociliary clearance (MCC). We have previously demonstrated that the regeneration of CF AE leads to a remodelled epithelium, the role of CF cell inflammatory memory in basal cell hyperplasia and increased CF AE height, the involvement of lung tissue inflammation in goblet cell hyperplasia, and the inflammationindependent default of ciliated cell differentiation. The identification of therapies favouring MCC through an improvement of CF AE regeneration is therefore crucial for CF patients. In this perspective, we examined the influence of an agro-based compound (A-bC) obtained by bacterial fermentation of wheat, on the regeneration of the human CF AE.