WS13.05 The short- and long-term effects of antibiotic treatment on the oropharyngeal and fecal microbiota in infants with cystic fibrosis

Abstract

Objectives: Infants with CF (IwCF) frequently receive systemic antibiotics for increased respiratory symptoms. The effects of these treatments on CF oropharyngeal (OP) and gastrointestinal (GI) microbiota are undefined, despite the importance of bacteria in both spaces: GI microbes impact immunity and nutrition, and OP samples serve increasingly as proxies for CF lower respiratory tract microbiology. Each site could also harbor transmissible antibiotic resistance determinants. Given that IwCF are relatively naïve to antibiotics, we compared the effects of one commonly-used antibiotic class- β-lactams- on the GI and OP microbiota of IwCF treated for new respiratory symptoms.