WS09.2 Radiation exposure in adults with CF attending Bristol Adult CF Centre

Abstract

Objectives As survival in CF adults increases their exposure to diagnostic ionising radiation is rising. Exposure to ≥10 milliSievert (mSv) per annum is sufficient to increase malignancy risk (O'Connell et al. 2012). We wished to estimate radiation exposure in our adult population and identify clinical risk factors for high exposure. Methods Total diagnostic radiation exposure (expressed as mean±SD mSv) over a twelve month period was calculated (using standard reference doses) for 196 patients attending our centre. Clinical parameters for those with high ( Results 591 investigations were performed. The average radiation dose was 3.7±8.8 mSv. Thoracic imaging accounted for 68% (91±84 mSv) and abdominal imaging 7% (6.3±0.04 mSv) of studies. 11% had high exposure (≥10 mSv – mean 21.3, maximum 88.9 mSv). CFRD, DIOS and infection with Pseudomonas aeruginosa (PsA) and Mycobacterium abscessus (Mabs) was more common in those with greater levels of radiation exposure, reflecting more significant disease in these individuals. Conclusion Care should be exercised when ordering ionising radiation investigations, particularly in those with higher burden of CF disease. TableDemographics of high and low exposure groupsFactorLow exposure,