WS08.06 Pilot study evaluating the potential of Akkermansia muciniphila and Faecalibacterium prausnitzii as cystic fibrosis-specific probiotics utilising patient-derived organoid models

Abstract

Objectives: Bacterial strains which occur differentially between CF and non-CF controls are linked to inflammatory and malignancy processes. Akkermansia muciniphila and Faecalibacterium prausnitzii have demonstrated anti-inflammatory effects and are consistently more abundant in healthy children but reduced in children with CF. Our primary objective was to quantify the inflammatory response to individual and combinations of species with known negative associations in CF, utilising patient-specific intestinal organoid models. Our secondary objective, was to evaluate if A. muciniphila and/or F. prausnitzii could improve inflammatory responses, demonstrating potential as CF-specific probiotics.