WS07.4 MBW and MRI as sensitive markers of stable CF lung disease and at exacerbation in children and adolescents

Abstract

Objectives MBW and MRI have both been shown to be sensitive outcome measures for CF lung disease. Therefore, we wanted to determine the correlation of the LCI with alterations in the MRI chest score as markers of CF lung disease under stable conditions and at exacerbation. Methods 57 stable children with CF (mean age, 9.5±6.2 years) had chest MRI scans performed. All children with CF and 106 healthy children (mean age, 8.9±4.8 years) underwent age-adapted MBW testing to assess LCI and to calculate LCI z-scores. 36 children (mean age, 13.9±4.4 years) were investigated at time of pulmonary exacerbation either via MRI (n = 10) or MBW (n = 26). Results Mean LCI z-score in healthy children was 0.1±1.2). LCI z-score was significantly higher in stable children with CF (5.4±5.5, P Conclusion LCI z-score and MRI chest score are elevated in CF and show a high correlation. Both methods are feasible and sensitive non-invasive markers of CF lung disease in children with CF under stable conditions and at time of exacerbation.