WS05.3 Sleep architecture in CF patients as assessed by the Body Media's SenseWear® Armband (SWA)

Abstract

Background Many CF patients complain of altered sleep quality and, in some of them, polysomnography shows sleep disorders with frequent awakenings, night cough, lower sleep efficiency (SE) and less REM sleep. The SWA, which measures body movement, surface body temperature, galvanic and heat flux skin response, proposes a non-invasive and simple way to measure sleep stages at home. Objectives Our study 1.examined the validity of SWA to detect sleep stages in normal controls compared to published normative values (Ohayon et al, Sleep 2004) and 2.compared SWA-derived sleep architecture between normal controls and stable CF patients. Methods 15 CF adults (31.6±12.3 yrs; FEV 1 65.5±24.4% pred) and 19 CF children (10.5±3.4 yrs; FEV 1 83±13.4%) were compared with 13 healthy adults (32.3±11.5 yrs) and 11 healthy children (10±1.9 yrs). CF patients and healthy subjects wore the SWA for an average of 5 and 2 nights, respectively. Light sleep (LS, stages 1 and 2), deep sleep (DS, stages 3 and 4); REM stage and SE were evaluated as the % of total sleep time. Results In healthy subjects, SWA showed SE and DS measures consistent with published normative values whereas LS and REM seemed to be over- and underestimated, respectively. In CF adults, but not in CF children, SE was lower when compared to normal controls (adults: 77.3±8.5% vs 86.3±4.7%; p=0.003; children: 81.0.3±6.8% vs 84.4±5.0%; p=0.154). None of the sleep stages differed between patients and controls, except for REM sleep which was lower in CF children. Conclusion SWA is a simple and promising method to detect sleep architecture disorders in CF patients, notably sleep efficiency.