WS04.4 Prevalence of vitamin D deficiency and effectiveness of two different high dose (stoss) oral vitamin D supplementation protocols in a paediatric cystic fibrosis clinic in Australia

Abstract

Objectives To determine the prevalence of 25-hydroxyvitamin D (25(OH)D) deficiency in children with cystic fibrosis (CF) in South Australia and to evaluate the effectiveness of 2 stoss vitamin D supplementation protocols. Methods A retrospective case-note review was conducted for 143 children with CF (0–18 years, 75 males) for the period Nov 2012-Sept 2014 where 25(OH)D levels were collected. In Nov 2012 a stoss protocol was adopted where children with inadequate 25(OH)D (defined as Results Vitamin D deficiency was observed in 69% of children (n = 98). 73 received stoss therapy. Serum 25(OH)D levels ≥2 months post stoss were available for 53 children. Both protocols increased mean±SD 25(OH)D levels significantly (71.2±25.3 vs 56.5±8.7 nmol/L, p Conclusion Vitamin D deficiency is highly prevalent in this population. Stoss therapy increases 25(OH)D levels however 51% of children did not achieve adequate vitamin D levels regardless of protocol used. Further investigation is required to improve the effectiveness of vitamin D supplementation.