WS02.02 Ovarian reserve in women with cystic fibrosis: is this a cause of subfertility?

Abstract

Background: Over the past two decades, increasing numbers of cystic fibrosis (CF) patients survive into adulthood. Accordingly, a dramatic increase in the number of pregnancies is documented in CF registries; however, compared to the general population, subfertility is an obstacle for many women with CF (wwCF). While it was initially assumed that mechanical factors, secondary to cervical mucous thickness, were the main cause of CF subfertility, it is now understood that this is only one factor among many. Decreased ovarian reserve has been proposed as a possible cause, but limited data is available to support this. The aim of this study was to evaluate the ovarian reserve in wwCF and to correlate this with patients’ demographic and clinical data.