Abstract

In 1983, Langston and colleagues reported that accidental exposure of humans to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces a Parkinsonian state ([1][1], [2][2]). The authors hypothesized that damage to the substantia nigra might reflect a selective toxicity of MPTP for dopaminergic

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