Abstract
Since the completion of the Human Genome Project (HGP-read), improvements of sequencing technology, dramatic reductions in sequencing cost, and importantly, progress in understanding of the function of the human genome have been continual. Recent advances in sequencing-based technologies and DNA-editing methods [e.g., CRISPR (clustered regularly interspaced short palindromic repeat)] present the possibility of synthesizing and editing DNA on a large scale. With these possibilities, a question is raised: would construction of large scale (0.1–1 billion bp) genomes lead to further understanding and applications of genomic information? A collaborative group called the Center of Excellence for Engineering Biology, led by New York University synthetic biologist Dr. Jef D. Boeke, formally announced the Human Genome Project-Write (HGP-write) in the …
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