Writing in prodromal and mild dementia with Lewy bodies: an exploratory and preliminary study

Abstract

In order to better characterize their cognitive profiles, our speech therapy study aimed to assess the ability of prodromal or mild DLB patients in writing production. Seventeen prodromal to mild DLB patients underwent written tests selected from the French language assessment corpus GREMOTS. The protocol included dictations of words, logatoms, and sentences. These tests were completed with a self-assessment questionnaire about writing disability and an observational table of writing behavior. 18% of patients had a deficit score in dictation of words, 41% of patients had a deficit score in dictation of logatoms and 35% of patients had a deficit score in dictation of sentences. 71% of patients had a subjective complaint about their handwriting quality. The assessment of handwriting quality also showed difficulties for 76% of patients, with graphic motor pattern disorders and motor symptoms associated with parkinsonism dysgraphia. Finally, our results suggest an impact of working memory, attentional and executive function impairments on logatoms production, and an impact of working memory impairment on long sentences production and grammatical agreements. These findings are promising and may improve our knowledge of the prodromal and mild stages of DLB. They may also contribute to improve early diagnosis and clinical practice.