Abstract
In eukaryotes, histone H3 lysine 9 methylation (H3K9me) mediates the silencing of invasive and repetitive sequences by preventing the expression of aberrant gene products and the activation of transposition. In Arabidopsis, while it is well known that dimethylation of histone H3 at lysine 9 (H3K9me2) is maintained through a feedback loop between H3K9me2 and DNA methylation, the details of the H3K9me2-dependent silencing pathway have not been fully elucidated. Recently, the regulation and the function of H3K9 methylation have been extensively characterized. In this review, we summarize work from the recent studies regarding the regulation of H3K9me2, emphasizing the process of deposition and reading and the biological significance of H3K9me2 in Arabidopsis.
Highlights
In eukaryotic cells, chromatin is divided into two major types of compartments: heterochromatin and euchromatin, reflecting the repressive and permissive potential for transcription in these regions, respectively (Ding et al, 2007)
In Arabidopsis, KYP, SUVH5, and SUVH6 are primarily recruited to the targets through SET and RING-associated (SRA) domain binding to DNA that is methylated in the CHG context (H stands for any base except G)
To enable plants to correctly deposit H3K9me2 in the genome, multiple H3K9 methyltransferases are in charge of H3K9me2 deposition in different sequence contexts via DNA methylation-dependent and -independent activities
Summary
Reviewed by: Paul Fransz, University of Amsterdam, Netherlands Liangsheng Zhang, Fujian Agriculture and Forestry University, China. Histone H3 lysine 9 methylation (H3K9me) mediates the silencing of invasive and repetitive sequences by preventing the expression of aberrant gene products and the activation of transposition. In Arabidopsis, while it is well known that dimethylation of histone H3 at lysine 9 (H3K9me2) is maintained through a feedback loop between H3K9me and DNA methylation, the details of the H3K9me2-dependent silencing pathway have not been fully elucidated. The regulation and the function of H3K9 methylation have been extensively characterized. We summarize work from the recent studies regarding the regulation of H3K9me, emphasizing the process of deposition and reading and the biological significance of H3K9me in Arabidopsis
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
