Wound repair and regenerating effect of ethyl acetate soluble fraction of ethanolic extract of Cinnamomum camphora leaves in wistar albino rats

Abstract

The leaves of Cinnamomum camphora are used in folk medicine for treatment of several skin disorders, anti-inflammatory disorders, various antimicrobial diseases and antioxidant activities. The aim of our study was to find the active fraction from ethanolic extract of C. camphora leaves responsible for wound healing activity in rats. The wistar albino rats were made wounded by the excision, incision and dead space wound on back side of rats. The ethylacetate soluble fraction of ethanolic extract of leaves of Cinnamomum camphora was applied topically in excision wound model while in incision and dead space wound model the Ethyl acetate soluble fraction (100 mg/kg) was give orally for 16 days. In the excision wound model the wound area and day of epithelization both were significantly decreased Ethyl acetate soluble fraction treated rats. In incision wound model the significantly higher tensile strength was observed in rats treaded orally with ethyl acetate soluble fraction. There were significant increase in weight of wet & dry granulation tissue with increased amount of hydroxyproline, collagen and elastin was observed in treated rats by ethyl acetate soluble fraction. The results suggested that the ethyl acetate soluble fraction of ethanolic extract of leaves of Cinnamomum camphora can be beneficial in treatment of wound healing in wistar albino rats. Keywords: Cinnamomum camphora, ethanolic extract, anti-inflammatory