Abstract
By means of morphological researches executed within an experimental framework it is identified that a considerable increase in endothelial monolayer covering the wound surface is immunohistochemically observed after NO-management of the wound. In turn, cryofractographic identification of small pits on splits of endotheliocytes indicates an increase in density of plasmalemmal vesicules in capillary endothelium of dermal and muscule tissue of the wound surface. Activation of the specified reactions promotes an intensification of neoangiogenesis as convincingly confirmed by a considerable increase in length of microvasculature in 1 mm3 of forming granulations, verified at scanning electronic microscopy. At the same time, the immunohistochemical research results indicate a considerable increase in proliferative activity of stab cells of epidermis of vulnar surfaces. The set of the listed changes reflects brightly pathogenetic positivity of the influence of exogenetic nitrogen monoxide on the course of wound process, mainly, on its reparative component.
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