Abstract
Summary and conclusionsIntraperitoneal injections of 20 mg/kg body weight of activated crude papain to rats resulted in a decrease in the concentration of acid polysac-charides in the normal skin. There was an initial delay in the various stages of wound healing in the skin. Retardation in differentiation of fibroblasts and maturation of reticular fibers into collagen bundles was observed. The depletion of acid polysaccha-rides from the connective tissue ground substance in wounds of papain treated animals was associated with a delay in the maturation of collagen.
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