Wound Healing Goes Viral

Abstract

During cutaneous wounding, many different cell types are mobilized to reinstate homeostasis, including immune cells, keratinocytes, dermal fibroblasts, and fascia fibroblasts. These responses are essential to stop bleeding, clear microbes, and close the wound to re-establish the skin barrier. Humans, similar to most mammals, are incapable of regenerating fully functional skin after cutaneous wound healing. Instead, scar tissue develops, which is inferior to native skin owing to its lack of skin appendages, unsightly appearance, and compromised mechanical properties (Marshall et al., 2018).