Abstract
Pruni Cortex has been used to treat asthma, measles, cough, urticaria, pruritus, and dermatitis in traditional Korean medicine. The objective of this study was to investigate the effects of Prunus yedoensis Matsumura bark methanol extract (PYE) on scald-induced dorsal skin wounds in rats. Scalds were produced in Sprague-Dawley rats with 100°C water and treated with 5% and 20% PYE (using Vaseline as a base), silver sulfadiazine (SSD), and Vaseline once a day for 21 days, beginning 24 hours after scald by treatment group allocation. The PYE-treated groups showed accelerated healing from 12 days after scald, demonstrated by rapid eschar exfoliation compared to the control and SSD groups. PYE-treated groups showed higher wound contraction rates and better tissue regeneration in comparison with the control group. Serum analysis showed that transforming growth factor beta 1 and vascular endothelial growth factor levels remained high or gradually increased up to day 14 in both PYE groups and then showed a sharp decline by day 21, implying successful completion of the inflammatory phase and initiation of tissue regeneration. These findings suggested that PYE is effective in promoting scald wound healing in the inflammation and tissue proliferation stages.
Highlights
Burn injuries cause considerable morbidity, mortality, and socioeconomic losses
On day 12, the scabs were falling off from the wound surface and wound sizes were decreased in Vaseline and Prunus yedoensis Matsumura bark methanol extract (PYE) groups but thick and dark brown scabs still remained in silver sulfadiazine (SSD) and control groups
On days 18 and 21, the wound surfaces were almost closed and wound sizes were smallest in PYE groups
Summary
Burn injuries cause considerable morbidity, mortality, and socioeconomic losses. Burns caused by hot liquids, are one of the most frequently reported forms of burn. More than 50% of preschool pediatric burn patients are scald injury patients [1]. Burn injuries, including scalds, result in mild-to-severe scars on the skin. Patients continuously experience serious psychological distress as well as physical pain. Better acute care and therapeutics are needed in burn management
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