Abstract
Objective: The purpose of the study was to investigate the acceleration of the wound healing properties from lemon pepper’s essential oil as the lemon pepper’s ointment.
 Methods: There were 20 Wistar rats as an animal trial divided into four sample groups, including control (ointment base), standard (Nebacetin®), 5% lemon pepper, and 10% lemon pepper ointment, and all groups were injured by electric soldier for 10 s. The wound contraction and epithelialization period were the parameters of wound healing activity.
 Result: Wound contraction as the parameter of wound healing showed significant difference between the standard and lemon pepper ointment (p<0.05). The lemon pepper ointment groups showed no significant wound contraction difference in each lemon pepper ointment concentration at the initial time of observation, however, it become more obvious at last period of observation. Furthermore, the epithelialization period did not showed any significant differences between standard, 5% or 10% lemon pepper ointment against the control group (p>0.05).
 Conclusion: It can be concluded that the lemon pepper ointment had the potential to accelerate wound healing activity.
Highlights
The most common and severe type of injuries is burn injury that leads to significant morbidity and mortality over the world
It can be concluded that the lemon pepper ointment had the potential to accelerate wound healing activity
This study performed phytochemical screening against fresh lemon pepper, and the fresh lemon pepper had some phytochemicals like alkaloid
Summary
The most common and severe type of injuries is burn injury that leads to significant morbidity and mortality over the world. The case of burn is found high in the low and middle-income countries account for 90% of burn cases and around 5–12% of all types of injuries in the world. Burn was fourth leading cause of injury after road traffic injuries, falls, and violence [1,2,3]. Around twothirds of burn injuries were found in the African, East Mediterranean, and Southeast Asia regions. The East Mediterranean and Southeast Asia regions’ annual incidence rate is around 187 and 243/100,000. Burn injury is the leading cause of disability-adjusted lifeyears lost in low- and middle-income countries [1,2]
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