Abstract
Once Antiphospholipid syndrome (APS) is diagnosed, risk profile of the patient will impact its management whether there was a previous thrombotic event or not, association with other autoimmune disorders, presence of other obstetrical complications as well as being currently pregnant. The current recommended regimen for preventing obstetrical complications. The current recommended regimen for preventing obstetrical complications includes low molecular weight Heparin and low dose aspirin. This regimen decreases the risk of miscarriage by only 54%. Here, we will review the studies that evaluated adding Hydroxychloroquine (HCQ) to the treatment of APS and how effective it would be.
Highlights
Antiphospholipid syndrome is an autoimmune disorder defined by the presence of either vascular thrombosis or characteristic obstetrical morbidities along with positive laboratory tests of circulating antibodies
Long term follow- up revealed that 50% of women with Antiphospholipid syndrome (APS) but without thrombotic events would develop vascular thrombosis during 3-10 years and 10% would develop systematic lupus erythematosus (SLE) [2]
In a small prospective cohort study of primary APS with previous venous thrombosis, HCQ was added to the oral anticoagulant (OA) in 20 patients while the other 20 patients were treated with OA alone
Summary
Would Hydroxychloroquine Be A New Promising Drug in Managing Antiphospholipid Syndrome?. Received: October 10, 2018; Published: October 15, 2018 *Corresponding author: Amani Mohsen, Obstetrics & gynecology consultant, Palestinian Red Crescent Society, Shatila Camp, Beirut, Lebanon
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