Abstract

BackgroundA position paper based on the collective experiences of Argus II Retinal Prosthesis System investigators to review strategies to optimize outcomes in patients with retinitis pigmentosa undergoing retinal prosthesis implantation.MethodsRetinal surgeons, device programmers, and rehabilitation specialists from Europe, Canada, Middle East, and the United States were convened to the first international Argus II Investigator Meeting held in Ann Arbor, MI in March 2015. The recommendations from the collective experiences were collected. Factors associated with successful outcomes were determined.ResultsFactors leading to successful outcomes begin with appropriate patient selection, expectation counseling, and preoperative retinal assessment. Challenges to surgical implantation include presence of staphyloma and inadequate Tenon’s capsule or conjunctiva. Modified surgical technique may reduce risks of complications such as hypotony and conjunctival erosion. Rehabilitation efforts and correlation with validated outcome measures following implantation are critical.ConclusionsBringing together Argus II investigators allowed the identification of strategies to optimize patient outcomes. Establishing an on-line collaborative network will foster coordinated research efforts to advance outcome assessment and rehabilitation strategies.

Highlights

  • A position paper based on the collective experiences of Argus II Retinal Prosthesis System investigators to review strategies to optimize outcomes in patients with retinitis pigmentosa undergoing retinal prosthesis implantation

  • Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinal diseases affecting over one million individuals worldwide with an estimated prevalence of 1 in 4000 [1]

  • Though RP can be caused by mutations in any of over 190 genes, all lead to degeneration of the photoreceptor layer of the retina [2]

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Summary

Methods

The first international investigators’ meeting of retinal surgeons, device programmers, and rehabilitation specialists was convened in Ann Arbor, Michigan, USA in March 2015. The aim of the meeting was to share collective experiences with patient selection, surgical technique, outcome assessment, device programming issues, rehabilitation challenges, and future directions. Participants were asked to share factors contributing to optimal surgical outcomes; success with fitting, assessment, and rehabilitation; and patient satisfaction. This manuscript is a report of these collective experiences and recommendations to optimize patient outcomes with the Argus II system

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