Abstract
The World Influenza conference comprised numerous plenary sessions and some panel discussions. The highlights of the meeting were the novel approaches to vaccine developments, particularly the use of live-attenuated viruses and baculovirus- or bacteriophage-derived virus-like particles as delivery vectors. Improvements in antigenicity have been demonstrated by thoroughly understanding the biology of the influenza virus; in particular, understanding which residues within the hemagglutinin protein correspond with plaque morphology in cell culture. At least two different bioinformatic approaches were discussed for the rationale design of peptide vaccines; these are naturally at a very early stage but data look promising. We were reminded by several presenters that although we were in the midst of a pandemic caused by the H1N1 swine-derived influenza strain, avian influenza strains were still circulating, and some were predicting more widespread infection with these strains in the future.
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