Abstract
This chapter focuses on the results of experiments conducted to study genetic control of immune responsiveness. Evidence for the presence of histocompatibility linked immune response (Ir) genes was presented or reviewed for a large number of antigens in the workshop. Two immune response genes associated with mouse immunoglobulin allotypes were also described. A brief discussion of the effect of polyanions in restoring the immune response not controlled by histocompatibility linked genes in genetically or surgically athymic mice was also given. It was pointed out that if immune response genes are linked with, but not identical to HL-An antigen, then studies of HL-A disease associations may fail to show such associations because of recombination in a random breeding population. This effect will be lessened if the linkage is very close, or if association of particular Ir and HL-A genes is selected for, or functionally related.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.