Abstract
This chapter focuses on the results of experiments conducted to study genetic control of immune responsiveness. Evidence for the presence of histocompatibility linked immune response (Ir) genes was presented or reviewed for a large number of antigens in the workshop. Two immune response genes associated with mouse immunoglobulin allotypes were also described. A brief discussion of the effect of polyanions in restoring the immune response not controlled by histocompatibility linked genes in genetically or surgically athymic mice was also given. It was pointed out that if immune response genes are linked with, but not identical to HL-An antigen, then studies of HL-A disease associations may fail to show such associations because of recombination in a random breeding population. This effect will be lessened if the linkage is very close, or if association of particular Ir and HL-A genes is selected for, or functionally related.
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