Abstract

If a vaccine for a disease—such as hepatitis  virus infection—could be produced in edible plant parts, acquiring immunization against the disease could be as simple as taking a bite. So goes the idea behind the work of cellular immunologist Yasmin Thanavala of Roswell Park Cancer Institute, Buffalo, N.Y., and biochemistry professor Charles J. Arntzen at Texas A&M University's Albert B. Alkek Institute of Biosciences & Technology, Houston, and their coworkers. Thanavala and Arntzen are developing a plant-based oral vaccine for hepatitis  virus infection based on this concept. About 300 million people are carriers of hepatitis  virus, says Thanavala. In the Far East, more than 70% of the population is infected. Individuals who do not clear the virus have a greatly increased incidence of developing cancer. two researchers see plant-based production as a possible way to make vaccines cheaper and more available in developing nations. The [hepatitis B] vaccine now is being ...

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