Abstract
Neuroimaging techniques applied to a variety of organisms-from zebrafish, to rodents to humans-can offer valuable insights into neuronal network properties and their dysfunction in epilepsy. A wide range of imaging methods used to monitor neuronal circuits and networks during evoked seizures in animal models and advances in functional magnetic resonance imaging (fMRI) applied to patients with epilepsy were discussed during the XIV Workshop on Neurobiology of Epilepsy (XIV WONOEP) organized in 2017 by the Neurobiology Commission of the International League Against Epilepsy (ILAE). We review the growing number of technological approaches developed, as well as the current state of knowledge gained from studies applying these advanced imaging approaches to epilepsy research.
Highlights
Epilepsy may be broadly defined by a state of enduring predisposition to seizures, which arise when the balance between excitation and inhibition is disrupted in the context of abnormal synchronization
Epileptogenesis can be examined at different “levels” of the nervous system: first at the level of the molecular building blocks including genes, proteins, ions and membranes[1], cells and circuits/synapses, and large-scale neuronal networks
A network perspective has a particular relevance in epilepsy, since structures within an epileptogenic network are thought to be involved in the generation and expression of seizures, and to the maintenance of the disorder[2]
Summary
Neuroimaging techniques applied to a variety of organisms from zebrafish, to rodents to humans can offer valuable insights into neuronal network properties and their dysfunction in epilepsy. A wide range of imaging methods used to monitor neuronal circuits and networks during evoked seizures in animal models and advances in fMRI applied to epilepsy patients were discussed during the XIV Workshop on Neurobiology of Epilepsy (XIV WONOEP) organised in 2017 by the Neurobiology Commission of the International League Against Epilepsy (ILAE). We review the growing number of technological approaches developed, as well as the current state of knowledge gained from studies applying these advanced imaging approaches to epilepsy research
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