Women with cardiac syndrome X exhibit features of the insulin resistance syndrome and impaired peripheral microvascular function

Abstract

Infarction (TIMI) frame count (CTFC) method. Endothelial function was studied in 27 patients with SCF ( 23 male, 4 female, mean age 47.6+ 6.7) and in 30 subjects (22 male, 8 female, mean age 47.5i7.4) with normal coronary flow (NCF). ResultsThe mean CTFC (CTFC,) was significantly higher in patients with SCF (45.6*9.6 frames, p<O.OOl). Reactive hyperemia was significantly lower than that in the NCF group ( 189+87 % vs. 310%176%, pcO.01). The flow-mediated diameter increase in SCF group was significantly smaller than that in the NCF group (3.48+0.10 % versus 9.1 l+O.lO %. p<O.OOl). The percent nitroglycerine-induced (NTG-induced) dilatation was not signifacantly different between patients with SCF and subjects with NCF (16.8+1.1 % versus 17.lkl.l %. p=O.87). Simple regression analysis showed that CTFC, was strongly and inversely related to percent of FMD (r=-0.29. p<O.Ol) in all subjects. When the patients with SCF were excluded, CTFC, was still inversely related to percent FMD (r=-0.36, pcO.O5).The CTFC, was also inversely related to NTG-induced dilatation in the 57 subjects (r=-0.23. p<O.O5). Multiple regression analysis showed that the CTFC, was inversely related to percent of FMD only (r=-0.37, p<O.O5). ConclusionsThese findings suggest that endothelial function is impaired in subjects with SCF and the CTFC was well correlated with endothelial dysfunction.