Abstract
Background: Chronic non-communicable diseases are the major causes of mortality in the world. However, few studies have investigated the association between multi-categories BMI and chronic diseases from perspective of sex stratification. This study aimed to investigate the risk of chronic diseases at different BMI levels, and to further explore whether BMI-health risk associations differ by sex.Methods: In total, 21,134 participants aged 19–65 years (60.4% men) from the Tianjin People's Hospital, Tianjin Union Medical Center-Health Management Center were recruited for this cross-sectional study. Sex-specific percentiles of BMI were calculated and divided into 11 categories according to the 2000 CDC growth charts. Health-related indicators, such as hyperglycemia, hypertension, non-alcoholic fatty liver diseases (NAFLD), hyperuricemia, etc., were used as dependent variables in this study. Statistical differences were tested by unpaired Mann–Whitney U-test and chi-squared test. Logistic regression models were used to examine the associations between BMI and health-related indicators.Results: The risk of hyperglycemia (OR: 1.67, 95%CI: 1.23–2.29), NAFLD (OR: 2.22, 95%CI: 1.74–2.85), hypertriglyceridemia (OR: 1.65, 95%CI: 1.28–2.12), and hyperuricemia (OR: 1.39, 95%CI: 1.12–1.72) in men began to increase significantly when BMI was in the range of 22.59–23.89 kg/m2. However, in women, the risk of hyperglycemia (OR: 3.02, 95%CI: 1.25-8.98) and hyperuricemia (OR: 1.94, 95%CI: 1.26–3.05) began to increase significantly when BMI was in the range of 22.76–23.62 kg/m2, and the risk of NAFLD (OR: 5.48, 95%CI: 2.49–14.47) began to increase significantly when BMI was in the range of 21.08–21.97 kg/m2. Besides, at the same BMI level, the risk of diseases in women were significantly higher than that in men, especially when BMI > 25 kg/m2.Conclusion: In the Chinese population, the risk of chronic diseases in women were significantly higher than that in men at the same BMI level, especially when BMI was >25 kg/m2. In addition, the risk of chronic diseases began to increase significantly when BMI was >21.97 kg/m2 in women and 23.89 kg/m2 in men. The results indicated that women should be more alert to the risk of chronic diseases caused by the increase of BMI than men.
Highlights
As a global public health issue, chronic non-communicable diseases (NCDs), including hypertension, diabetes, hypercholesterolemia, cardiovascular diseases etc., are the major causes of mortality in the world, especially in developing countries
A large number of studies have explored the predictive value of body mass index (BMI) for the risk of chronic diseases by categorizing the population into normal, overweight, and obesity. [11, 12] Obesity control can effectively improves the health of individuals
It can be seen that the prevalence of the diseases studied is rising rapidly with the increase of BMI, especially in non-alcoholic fatty liver diseases (NAFLD) and hypertension
Summary
As a global public health issue, chronic non-communicable diseases (NCDs), including hypertension, diabetes, hypercholesterolemia, cardiovascular diseases etc., are the major causes of mortality in the world, especially in developing countries. As a common risk factor for NCDs, has been shown to be closely associated with various diseases [5,6,7] and health-related biochemical indicators [8,9,10]. Chronic non-communicable diseases are the major causes of mortality in the world. Few studies have investigated the association between multi-categories BMI and chronic diseases from perspective of sex stratification. This study aimed to investigate the risk of chronic diseases at different BMI levels, and to further explore whether BMI-health risk associations differ by sex
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