Women and Stroke: Disparities in Clinical Presentations, Severity, and Short and Long-Term Outcome (P6-5.003)

Abstract

<h3>Objective:</h3> There is limited data on sex-related short-term and long-term stroke outcomes from the Middle East. We present the eight years of our Qatar stroke database. <h3>Background:</h3> NA <h3>Design/Methods:</h3> The Qatar stroke database is a prospective study, which began enrolling patients in 2014. We collected data on the demographics, clinical presentation, investigations, treatments, hospital complications and outcome (measured as 90-days modified Rankin Score [mRS]) on all patients admitted with acute stroke to the Hamad General Hospital where ~95% of stroke patients in Qatar are admitted. Multivariate analysis of risk factors, stroke type and severity, and in-hospital complications were compared to determine 90-days and one-year outcome in men and women. <h3>Results:</h3> 7300 patients (F: 1406 {19.3%} and M: 4894 {80.7%}, mean age 55.1±13.3 {F 61.6±15.1, M 53.5±12.3; p&lt;0.001}) were admitted with acute ischemic stroke. Significantly fewer females presented within the 4.5 hours of onset [F: 29% versus M: 32.8%; p = 0.01]. Women had more severe stroke [NIHSS &gt;10; F: 19.9 % versus M: 14.5 %; P &lt;0.001]. Thrombolysis was less likely to be offered to women [F: 9.8% versus M: 12.1%; p 0.02]. Medical complications were more common in women [F: 11.7% versus M: 7.4%; p&lt;0.001] and females had a prolonged length of stay in hospital [F: 6.4±7.6 versus M: 5.5±6.8; p&lt;0.001]. 90-days good recovery was less frequent in women [mRS of 0–2: F: 53.3% versus M: 71.2%; p&lt;0.001]. Poor prognosis increased with age. <h3>Conclusions:</h3> In this large series of prospectively collected acute stroke patients from Qatar, our study reveals that women are more likely to have a poor outcome when compared to men. Although there was a higher incidence of obesity and previous CAD in women, we were unable to explain the reasons for the poor outcome at 90 days and one year. <b>Disclosure:</b> Ms. Naveed has nothing to disclose. Miss Almasri has nothing to disclose. Mr. Kazani has nothing to disclose. Miss Nauman has nothing to disclose. Dr. Singh has nothing to disclose. Dr. Al Jerdi has nothing to disclose. Dr. Akhtar has nothing to disclose. Dr. Shuaib has nothing to disclose.