Abstract
Maternal age is related to a higher risk of adverse maternal, fetal, and neonatal outcomes in twin pregnancies. However, whether this increase in adverse outcomes is due solely to age or due to risk factors that are more common in women over 40 remains unknown. The aim of this study is to assess if maternal age over 40 years old is an independent risk factor for obstetric adverse outcomes in dichorionic diamniotic twin gestations. In this single-center retrospective cohort study, we compared the obstetric outcomes of women with dichorionic diamniotic twin pregnancies below and over 40 years of age. A twin pregnancy cohort enrolled between 2013 and 2019 was included in the study. Maternal, fetal, and labor complications were recorded. A total of 510 women were analyzed in two groups: 266 women below 40 years old and 244 women over 40 years old. Maternal age over 40 increased the odds of maternal (aOR = 1.9 (1.3; 2.9); p-value = 0.002), fetal (aOR = 1.8 (1.0; 3.0); p-value = 0.037), and labor complications (aOR = 2.5 (1.3; 4.6); p-value = 0.004). Maternal age over 40 years was the most important factor increasing the odds of having a caesarean section (C-section). Over 40 years old was an independent risk factor for complications in dichorionic diamniotic twin pregnancies.
Highlights
In the FASTER trial, a multicenter study of singleton pregnancies, maternal age was found to be independently associated with specific adverse outcomes, such as miscarriage, congenital and chromosomal anomalies of the fetus, gestational diabetes, placenta previa, and a higher rate of
Pregnant women attending in the Obstetrics and Gynecology department of the ber 2019 were enrolled in this study
Our results showed that being over 40 years old in dichorionic diamniotic twin pregnancies was an important factor that increases the fold of maternal, fetal, and labor complications during pregnancy
Summary
Several reasons have been suggested for this phenomenon such as the increase in women’s academic status, financial security and employment access, the family–work conflict, issues finding a suitable partner, the use of contraception, and family policies [3,4,5,6]. Health problems such as immune disease, hypertension, diabetes mellitus, or psychological difficulties, such as depression and anxiety, increase with age [7]. Advanced maternal age during pregnancy may have age-related physical and psychological complications during gestation. In the FASTER trial, a multicenter study of singleton pregnancies, maternal age was found to be independently associated with specific adverse outcomes, such as miscarriage, congenital and chromosomal anomalies of the fetus, gestational diabetes, placenta previa, and a higher rate of
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