Abstract
Multipotent somatic stem cells with neural-crest-like characteristics have been identified in the dermis of human skin. These neural-crest-like stem cells (NCSCs) are capable of forming spheres, express neural crest stem cell markers, display extensive self-renewal capacity, and differentiate into several neural crest derivatives, including melanocytes and neural cells. So far, little is known about the biology of NCSCs. Here, we examined the role of Notch and Wnt signaling on the self-renewal and differentiation properties of NCSCs.
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