Abstract
In response to injury, epithelial cells migrate and proliferate to cover denuded mucosal surfaces. The epithelial reparative response is influenced by inflammation at sites of injury. Wnt‐b catenin signaling plays an important role in controlling intestinal epithelial homeostasis. We identified increased expression of a WNT1‐inducible signaling protein 1 (WISP1) in biopsy‐induced resealing intestinal mucosal wounds. WISP1 treatment of model intestinal epithelial cell (IEC) lines in vitro promotes wound repair by increasing epithelial cell proliferation. WISP1 associates with LRP6 and b1 integrin that are cell surface transmembrane proteins. Analysis of the signaling pathways revealed activation of src and Akt that promote epithelial cell proliferation and ultimately wound repair. In vivo analysis of healing intestinal mucosal wounds in response to biopsy‐induced injury demonstrated upregulation of WISP1 mRNA and protein in resealing intestinal mucosal wounds. Increased secretion of WISP1 in response to the anti‐inflammatory cytokine IL‐10 was observed in healing murine intestinal mucosal wounds. Lastly, WISP1 mRNA and protein was upregulated in human biopsies from patients with active inflammatory bowel disease. In summary, the above findings demonstrate an important role of WISP1 in promoting intestinal mucosal wound repair.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
