Abstract
WNT/β-catenin信号通路是一组进化性保守的信号，其在多种物种的胚胎发育以及再生中都发挥着重要的作用。本文综述了最近对WNT/β-catenin信号通路在多种脊椎动物器官损伤中作用的理解。在斑马鱼的视网膜和侧线再生，两栖动物的附肢再生以及小鼠中视网膜、生长板和前列腺再生中，此信号通路都发挥着至关重要的作用。 The WNT/β-catenin pathway is a set of evolutionarily conserved signals which play a vital role during embryonic development and regeneration of varied species. This paper reviews the recent understanding of the role of WNT/β-catenin pathway in various vertebrates’ injured organs. The WNT/β-catenin pathway is essential in the regeneration of retina and lateral line in zebrafish, limb regeneration in amphibian and regeneration of retina, growth plate cartilage and prostate in rat.
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