Abstract
The document associated with this DOI has been withdrawn.
Highlights
Despite recent improvements in survival because of advances in treatment, quality of life of patients with lymphoma may be compromised by long-term complications of chemo and steroid therapy [1]
Baseline testing of bone mineral density (BMD) reveals osteopenia or osteoporosis in the majority of Non Hodgkin lymphoma (NHL) patients[4].Patients with lymphoma have significant bone loss compared to the normal general population[5], because it is known that the therapy of lymphoma with high-dose glucocorticoids and alkylating agents may result in premature bone loss, increasing the risk of vertebral and hip fractures
Vitamin D has a stimulating effect on both calcium and phosphate homeostasis, playing a key role in providing adequate mineral for normal bone formation [12].High levels of parathyroid hormone (PTH) and/or low levels of Vitamin D can promote the onset of osteoporosis
Summary
Despite recent improvements in survival because of advances in treatment, quality of life of patients with lymphoma may be compromised by long-term complications of chemo and steroid therapy [1]. Glucocorticoids increase bone resorption and reduce bone formation by inhibiting the formation of osteoblast precursors and inducing apoptosis of mature osteocytes They determine a reduction in intestinal absorption of calcium and muscle mass. Vitamin D has a stimulating effect on both calcium and phosphate homeostasis, playing a key role in providing adequate mineral for normal bone formation [12].High levels of PTH and/or low levels of Vitamin D can promote the onset of osteoporosis. Despite recent improvements in survival due to advances in treatment, the quality of life of patients with lymphoma may be compromised by the long-term complications of chemotherapy and steroid therapy. The most benefited subpopulations could be elderly and young patients
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