WITHDRAWN

Abstract

TYPE: Abstract TOPIC: Biotechnology PURPOSE: Development of diaphragmatic paralysis/paresis may lead to dyspnea, respiratory distress, and even respiratory failure.In prolonged cases, the diaphragm atrophies, which renders surgical palliation or pacemaker ineffective.To address this pervasive issue, we have designed and pilot-tested an artificial diaphragm. METHODS: We embedded nano-electromagnetic coils in an elastic polymeric non-immunogenic resin plate.Two plates were superimposed: the top plate is superiorly convex and mobile; the lower plate is flat, and the edges are sutured to adjacent tissues.The device is inserted into the deficiency left by the paralyzed diaphragm.Passing current through the coils, activates the magnetic fields of the plates: if they are charged opposingly, the top mobile plate moves towards the inferior fix plate, pulling the convex portion down, increasing the lung volume(i.e., inspiration).When the currents are reversed (similar magnetic fields), the plates repel each other: the convex plate moves upward, compressing the lung(i.e., expiration).This two-plate package is connected to and controlled by a rechargeable microchip and synchronized with stimulations of the phrenic nerve, to adjust with the respiration rate. RESULTS: We built and surgically affixed the artificial diaphragm double-set to the resected diaphragm of a sheep cadaver model.The sheep was intubated and attached to a mechanical ventilator, set on spontaneous (CPAP) mode with zero pressure support or PEEP.The diaphragm-model generated volumes of up to 850 ML/breath, with MIP=18cmH2O and MEP=14cmH2O. CONCLUSIONS: This device was pilot tested to mimic the inspiratory/expiratory motions of the diaphragm when tested on a cadaveric animal model.It must now be tested on a live animal model. CLINICAL IMPLICATIONS: Assist ventilation, improving patients' QOL. DISCLOSURE: Nothing to declare. KEYWORD: diaphragmatic assist device