WITHDRAWN: Target region sequencing and gene polymorphism of Chinese Uyghur individuals with autoimmune thyroid diseases (AITDs)

Xin-Ling Wang,Yun-Zhi Luo,Yan-Ying Guo,Meng-He Wang,Su-Li Li,Yuan Chen,Jamilam Mamtiming,Jing Zhang

doi:10.18632/oncotarget.23244

Abstract

// Xin-Ling Wang 1 , Meng-He Wang 1 , Yan-Ying Guo 1 , Su-Li Li 1 , Jing Zhang 1 , Yuan Chen 1 , Jamilam Mamtiming 1 and Yun-Zhi Luo 1 1 Department of Endocrinology, People’s Hospital of Xinjiang Uyghur Autonomous Region, Urumqi 830000, Xinjiang, China Correspondence to: Yan-Ying Guo, email: guozeyang@126.com Keywords: AITDs; target region sequencing; single nucleotide polymorphism (SNP); Uyghur individuals; Gerotarget Received: November 27, 2017 Accepted: December 08, 2017 Published: December 14, 2017 ABSTRACT The autoimmune thyroid diseases (AITDs) can mainly involve complex interactions between environmental exposure and genetic susceptibility. At present, a majority of AITDs relative genes have been identified, but the results of different ethnic origin are inconsistent. Due to the special genetic characteristics of Uyghur and the unique environment of Xinjiang Uyghur Autonomous Region, the specific pathogenesis of AITDs Uyghur patients remains unknown. Our study was carried out in the group of 100 AITDs Uyghur patients (50 GD and 50 HT) and 50 Uyghur controls. DNA was extracted from peripheral blood leukocytes and region sequencing was performed to identify candidate genes and single nucleotide polymorphisms (SNPs). Following quality control, Chi-square and logistic regression tests were used for detecting the different frequencies of genotypes and alleles between cases and controls. The results of our analyses showed that the polymorphisms of TPO, TG, TSHR and PTPRC genes were associated with AITDs Uyghur patients; CD28, TPO, PTPRC and TG were related to GD; TG, STAT3 and IL2RA were connected with HT. In conclusion, our study may explore several SNPs associate with AITDs in Chinese Uyghur individuals.

Highlights

Autoimmune thyroid diseases (AITDs) are a series of typical organ-specific autoimmune endocrine disorders, among which GD (Graves’ disease) and HT (Hashimoto’s thyroiditis) are most common [1]
The results of our analyses showed that the polymorphisms of TPO, TG, TSHR and PTPRC genes were associated with AITDs Uyghur patients; CD28, TPO, PTPRC and TG were related to GD; TG, STAT3 and IL2RA were connected with HT
They found the polymorphisms of CD40 and FCRL3 were associated with GD and the polymorphisms of ZFAT were associated with HT, which demonstrated that multiple genes could be common to both diseases and some were www.impactjournals.com/oncotarget unique

Summary

Introduction

Autoimmune thyroid diseases (AITDs) are a series of typical organ-specific autoimmune endocrine disorders, among which GD (Graves’ disease) and HT (Hashimoto’s thyroiditis) are most common [1]. The results of our analyses showed that the polymorphisms of TPO, TG, TSHR and PTPRC genes were associated with AITDs Uyghur patients; CD28, TPO, PTPRC and TG were related to GD; TG, STAT3 and IL2RA were connected with HT. To better understand the etiology of AITDs, our aim of the present study is to identify novel genes and loci which are common or unique for GD and HT Uyghur patients.

Results

Conclusion