Abstract
WITHDRAWN: Sarcopenia as a leading risk factor for erosive esophagitis
Highlights
Gastroesophageal reflux disease is a widespread gastrointestinal disorder that frequently occurs in primary care settings, imposing considerable burdens on global health and economics [1]
In a multivariable model adjusted for age, sex, smoking status, alcohol intake, regular exercise, and metabolic variables, the risk of erosive esophagitis was higher in obese [adjusted odds ratio(aOR), 1.38; 95% confidence interval (CI), 1.26–1.52], sarcopenic, and sarcopenic obese participants than in normal participants
Comparing sarcopenic and sarcopenic obese participants to obese participants, the odds ratios (ORs) for erosive esophagitis were 1.59 and 1.22, respectively
Summary
Gastroesophageal reflux disease is a widespread gastrointestinal disorder that frequently occurs in primary care settings, imposing considerable burdens on global health and economics [1]. Obesity is considered a significant contributing factor for a spectrum of reflux-related esophageal disorders ranging from www.impactjournals.com/oncotarget erosive esophagitis to Barrett’s esophagus to esophageal adenocarcinoma [3, 4]. The exact mechanisms have not been fully identified, several studies have demonstrated that the pattern of body fat distribution may be more important than general adiposity for increasing the risk of erosive esophagitis [5, 6]. The reflux-independent effect of adiposity on erosive esophagitis may contribute to the association, which cannot be solely explained by the mechanical effect of obesity
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