WITHDRAWN: Epicardial Adipose Tissue: A Marker of Coronary Artery Disease in Patients with Heart Failure with Preserved Ejection Fraction

Abstract

BackgroundEpicardial adipose tissue (EAT) is closely associated with the pathophysiological processes of heart failure with preserved ejection fraction (HFpEF). However, it remains unknown whether EAT increases the risk of coronary artery disease (CAD) in patients with HFpEF. MethodsThis was a retrospective cohort study in 112 HFpEF patients hospitalized in the First Affiliated Hospital of Chongqing Medical University from September 2021 to May 2022, who undergoing at least once coronary artery examination. The thickness of EAT was measured by echocardiography. The correlation between EAT and CAD was analyzed by multifactorial binary logistic regression. ResultsCompared to patients without CAD, EAT thickness was noticeably higher in patients with CAD (P = 0.002). Spearman correlation analysis showed that CAD (r = 0.289, P = 0.002) and Gensini score (r = 0.334, P < 0.001) were positively correlated with EAT thickness. Furthermore, after adjusted for age, gender, body mass index, hypertension, type 2 diabetes mellitus, smoking history and a part of biochemical indexes, EAT thickness was associated with CAD (OR ranged from 1.450 to 1.472, all P values ＜0.05). ConclusionsEAT thickness was correlated with CAD in patients with HFpEF.