WITHDRAWN: Diffusion kurtosis imaging (DKI) in characterization in indetermined solitary pulmonary nodules (SPNs): comparison with conventional DWI and quantitative

Abstract

We contrasted traditional DWI with quantitative imaging to better understand the function of diffusion kurtosis imaging (DKI) in characterising solitary pulmonary nodules (SPNs).Forty-seven consecutive patients with SPNs (30 males, 17 females, median age: 61 years; range: 29 to 86 years) were included in this paper between March 2018 and July 2020. Quantitative DCE-MRI and multi-b factor DWI (b values ranging from 0 to 2000 sec/mm2) were obtained. We compared the ADC, Kapp, Dapp, Ktrans, Kep, Ve, and iAUC values between the malignant and benign groups, as well as between the various LC subtypes. The purpose of the ROC curves was to evaluate the diagnostic value.Kapp, Ktrans, Ve and iAUC values were obviously higher for malignant SPNs compared to that of benign SPNs (P < 0.035). ADC was obviously higher in benignity compared to malignant SPNs (P = 0.001). There exist no obvious difference in Dapp and Kep between the two groups (P = 0.06). Kapp value has highest sensitivity (81.8%) and accuracy (75.7%), and ADC value has highest specificity (80.0%). Combination of ADC and iAUC enhanced the sensitivity to 81.8%, specificity to 86.7% and precision to 83.8%.