Abstract
WITHDRAWN: Correlation between FOXP1 and ER/PR expression in endometrial carcinoma
Highlights
Endometrial carcinoma is one of three most common malignancies of the female reproductive system; its morbidity trend has increased in recent years, and its mortality is the second highest, after ovarian cancer, in several developed countries [1]
Interactions were found between estrogen receptor β with both Forkhead box protein 1 (FOXP1) and estrogen receptor α in Ishikawa cells
FOXP1 is poorly expressed in endometrial carcinoma and associated with the low expression of estrogen receptor and progesterone receptor, as well as the shorter survival time
Summary
Endometrial carcinoma is one of three most common malignancies of the female reproductive system; its morbidity trend has increased in recent years, and its mortality is the second highest, after ovarian cancer, in several developed countries [1]. Forkhead box protein 1 (FOXP1), a member of the forkhead transcriptional factor family, known as MFH, QRF1 or hFKH1B, is widely present in several types of normal organ cells and has many physiological functions. It plays an important role in the regulation of B cell development and monocyte differentiation, and participates in cardiac valve morphodifferentiation and lung development [4]. Numerous studies have shown that the expression level of FOXP1 shows a marked change in tumor tissues, being lower in renal, breast, ovarian, lung and prostate cancers than in normal tissues [5,6,7,8,9,10], but is increased in malignant tumors such as lymphoma, which indicates that FOXP1 may have other roles except as an anti-oncogene [11,12,13]
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