WITHDRAWN: Associations between ten VEGF gene polymorphisms and susceptibility to type 2 diabetic retinopathy, proliferative diabetic retinopathy and nonproliferative diabetic retinopathy: a systematic review and meta-analysis

Abstract

// Qianhui Yang 1 , Yan Zhang 1 , Xiandi Wang 2 , Xiaomin Zhang 1 and Xiaorong Li 1 1 Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute and Tianjin Medical University School of Optometry and Ophthalmology, Tianjin, China 2 Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China Correspondence to: Xiaorong Li, email: lixiaorong@tmu.edu.cn Keywords : VEGF; gene polymorphism; diabetic retinopathy; meta-analysis Received : July 03, 2017 Accepted : December 27, 2017     Epub: January 03, 2018     Abstract The associations between VEGF gene polymorphisms and risk of type 2 DR, PDR and NPDR remian unclear. A systematic search and meta-analysis using OR with 95% CI was performed to evaluate the association. 26 studies containing 10 SNPs were analyzed. rs3025039 polymorphism was associated with DR risk in overall and Asian populations. rs2010963 was associated with increased of DR risk in overall populations and Caucasians. There was a significant association between rs25648 and rs833061 and DR risk in Caucasians. Significant associations were observed between rs3025021, rs13207351 and rs2146323 and DR risk in either overall populations, Caucasians or Asians. rs699947 and rs3025039 were associated with PDR risk in overall and Asian populations. rs1570360, rs3025039 and rs833061 played a key role in PDR etiology in Caucasians. rs2010963 was associated with increased risk of PDR in overall populations. A significant association between rs699947, rs3025039 and rs833061 and NPDR risk in overall populations and Asians was found. A significant association was observed between rs2010963 and increased NPDR risk in overall and Caucasian populations. This study provides a new insight into the parthenogenesis of diabetic retinopathy. Targeting VEGF SNPs may be a potential of therapeutic approach for the treatment of DR, PDR and NPDR.