WITHDRAWN: Association between body mass index (BMI) and carotid intimamedia thickness in patients with type 2 diabetes mellitus: results from the PROLOGUE study

Abstract

// Ziliang Ye 1,3 , Haili Lu 2,3 , Qiang Su 1 and Lang Li 1 1 Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China 2 Department of Orthodontic, The Affiliated Dental Hospital of Guangxi Medical University, Nanning, Guangxi, China 3 Guangxi Medical University, Nanning, Guangxi, China Correspondence to: Lang Li, email: drrlilang@126.com Keywords : body mass index; carotid intima-media thickness; type 2 diabetes; PROLOGUE study Received: July 28, 2017 Accepted: December 18, 2017 Epub: January 08, 2018 Abstract Background: The aim of our study was to explore the association between body mass index (BMI) and carotid intima-media thickness (IMT) in patients with type 2 diabetes mellitus (T2DM). Methods: In the PROLOGUE study, 442 patients with T2DM were recruited. BMI and carotid IMT were measured at the beginning of the study. Patients were divided into four groups according to BMI [BMI <18.5 kg/m 2 (underweight), 18.5≤BMI<24.9 kg/m 2 (normal weight), 25≤BMI<30 kg/m 2 (overweight) and BMI≥30.0 kg/m 2 (obese)]. Result: For male patients, there were significant differences in the carotid IMT level between the four groups [0.87±0.13 (underweight), 0.86±0.23 (normal weight), 0.81±0.17 (overweight) and 0.76±0.15 (obese), P= 0.041, respectively]. However, after adjusting for potential confounding factors, BMI is not associated with carotid IMT [underweight: -0.05 (-0.31, 0.20); overweight: -0.08 (-0.17, 0.01); obese: -0.16 (-0.35, 0.03), normal weight served as a reference group]. For female patients, there were not significant differences in the carotid IMT level between the four groups [0.79±0.21 (underweight), 0.82±0.15 (normal weight), 0.80±0.15 (overweight) and 0.81±0.16 (obese), P=0.813, respectively]. However, after adjusting for potential confounding factors, obese is strongly associated with carotid IMT [underweight: -0.10 (-0.26, 0.05); overweight: 0.09 (0.00, 0.19); obese: 0.29 (0.09, 0.49), normal weight served as a reference group]. Conclusions: Our findings suggest that BMI is not associated with carotid IMT in male patients. In contrast, the carotid IMT level is markedly thickened in obesity women patients when comparing with the normal weight group. More research is needed to confirm this conclusion. Trial Registration: University Hospital Medical Information Network Clinical Trials Registry UMI04490.