Abstract
VOLUME 293 (2018) PAGES 19025–19037 This article has been withdrawn by the authors except Stuart Jarrett, who could not be reached. The withdrawing authors were unable to provide original data corresponding to many of the micrographs presented in the article according to Journal policy. In Fig. 3D, the PLA images for XPA-WT, XPA-K63Q, and XPA-K67Q were duplicated. Also in Fig. 3D, the DAPI merged images for XPA-WT and XPA-K63Q were duplicated. Sirtuin 1-mediated deacetylation of XPA DNA repair protein enhances its interaction with ATR protein and promotes cAMP-induced DNA repair of UV damageJournal of Biological ChemistryVol. 293Issue 49PreviewBlunted melanocortin 1 receptor (MC1R) signaling promotes melanocyte genomic instability in part by attenuating cAMP-mediated DNA repair responses, particularly nucleotide excision repair (NER), which recognizes and clears mutagenic photodamage. cAMP-enhanced NER is mediated by interactions between the ataxia telangiectasia-mutated and Rad3-related (ATR) and xeroderma pigmentosum complementation group A (XPA) proteins. We now report a critical role for sirtuin 1 (SIRT1) in regulating ATR-mediated phosphorylation of XPA. Full-Text PDF Open Access
Highlights
This article has been withdrawn by the authors except Stuart Jarrett, who could not be reached
The withdrawing authors were unable to provide original data corresponding to many of the micrographs presented in the article according to Journal policy
The DAPI merged images for XPA-WT and XPA-K63Q were duplicated
Summary
This article has been withdrawn by the authors except Stuart Jarrett, who could not be reached.
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